Preoperative lymphopaenia, mortality, and morbidity after elective surgery: systematic review and meta-analysis.

ABSTRACT:

Background

In the general adult population, lymphopaenia is associated with an increased risk for hospitalisation with infection and infection-related death. The quality of evidence and strength of association between perioperative lymphopaenia across different surgical procedures and mortality/morbidity has not been examined by systematic review or meta-analysis.

Methods

We searched MEDLINE, Embase, Web of Science, Google Scholar, and Cochrane databases from their inception to June 29, 2020 for observational studies reporting lymphocyte count and in-hospital mortality rate in adults. We defined preoperative lymphopaenia as a lymphocyte count 1.0-1.5×10⁹ L^-1. Meta-analysis was performed using either fixed or random effects models. Quality was assessed u

SUBMITTER: Schroth J 

PROVIDER: S-EPMC8258977 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature