The miR-200-Zeb1 axis regulates key aspects of β-cell function and survival in vivo.

ABSTRACT:

Objective

The miR-200-Zeb1 axis regulates the epithelial-to-mesenchymal transition (EMT), differentiation, and resistance to apoptosis. A better understanding of these processes in diabetes is highly relevant, as β-cell dedifferentiation and apoptosis contribute to the loss of functional β-cell mass and diabetes progression. Furthermore, EMT promotes the loss of β-cell identity in the in vitro expansion of human islets. Though the miR-200 family has previously been identified as a regulator of β-cell apoptosis in vivo, studies focusing on Zeb1 are lacking. The aim of this study was thus to investigate the role of Zeb1 in β-cell function and survival in vivo.

Methods

miR-200 and Zeb1 are involved in a double-negative feedback loop. We characterized a mouse model in which miR-

SUBMITTER: Title AC 

PROVIDER: S-EPMC8258987 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature