Amiloride ameliorates muscle wasting in cancer cachexia through inhibiting tumor-derived exosome release.

ABSTRACT:

Background

Cancer cachexia (CAC) reduces patient survival and quality of life. Developments of efficient therapeutic strategies are required for the CAC treatments. This long-term process could be shortened by the drug-repositioning approach which exploits old drugs approved for non-cachexia disease. Amiloride, a diuretic drug, is clinically used for treatments of hypertension and edema due to heart failure. Here, we explored the effects of the amiloride treatment for ameliorating muscle wasting in murine models of cancer cachexia.

Methods

The CT26 and LLC tumor cells were subcutaneously injected into mice to induce colon cancer cachexia and lung cancer cachexia, respectively. Amiloride was intraperitoneally injected daily once tumors were formed. Cachexia features of the CT

SUBMITTER: Zhou L 

PROVIDER: S-EPMC8258996 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature