Two homologous Salmonella serogroup C1-specific genes are required for flagellar motility and cell invasion.

ABSTRACT:

Background

Salmonella is a major bacterial pathogen associated with a large number of outbreaks of foodborne diseases. Many highly virulent serovars that cause human illness belong to Salmonella serogroup C1, and Salmonella ser. Choleraesuis is a prominent cause of invasive infections in Asia. Comparative genomic analysis in our previous study showed that two homologous genes, SC0368 and SC0595 in Salmonella ser. Choleraesuis were unique to serogroup C1. In this study, two single-deletion mutants (Δ0368 and Δ0595) and one double-deletion mutant (Δ0368Δ0595) were constructed based on the genome. All these mutants and the wild-type strain were subjected to RNA-Seq analysis to reveal functional relationships of the two serogroup C1-specific genes.

Results

Data from RNA-Seq indi

SUBMITTER: Zhou X 

PROVIDER: S-EPMC8259012 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature