Reversible increase in maximal cortisol secretion rate in septic shock.

ABSTRACT:

Objective

Cortisol clearance is reduced in sepsis and may contribute to the development of impaired adrenocortical function that is thought to contribute to the pathophysiology of critical illness-related corticosteroid insufficiency. We sought to assess adrenocortical function using computer-assisted numerical modeling methodology to characterize and compare maximal cortisol secretion rate and free cortisol half-life in septic shock, sepsis, and healthy control subjects.

Design

Post hoc analysis of previously published total cortisol, free cortisol, corticosteroid-binding globulin, and albumin concentration data.

Setting

Single academic medical center.

Patients

Subjects included septic shock (n = 45), sepsis (n = 25), and healthy controls (n = 10).

Interven

SUBMITTER: Dorin RI 

PROVIDER: S-EPMC8259018 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature