A protein A based Staphylococcus aureus vaccine with improved safety.

ABSTRACT: Exposure to Staphylococcus aureus does not lead to immunity as evidenced by the persistent colonization of one third of the human population. S. aureus immune escape is mediated by factors that preempt complement activation, destroy phagocytes, and modify B and T cell responses. One such factor, Staphylococcal protein A (SpA) encompasses five Immunoglobulin binding domains (IgBDs) that associate with the Fcγ domain to block phagocytosis. IgBDs also associate with Fab encoded by V_H3 clan related genes. SpA binding to V_H3-IgM that serves as a B cell receptor results in B cell expansion and secretion of antibodies with no specificity for S. aureus. SpA crosslinking of V_H3-IgG and V_H3-IgE bound to cognate receptors of mast cells and basophils promote

SUBMITTER: Shi M 

PROVIDER: S-EPMC8259053 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature