Cobalt-Catalyzed C-H Activation/Annulation of Benzamides with Fluorine-Containing Alkynes: A Route to 3- and 4-Fluoroalkylated Isoquinolinones.

ABSTRACT: The C-H activation/annulation reaction of various benzamides with fluoroalkylated alkynes in the presence of a Co(acac)₂·2H₂O catalyst proceeded very smoothly to give the corresponding 3- and 4-fluoroalkylated isoquinolinones in excellent yields with approximately 70% regioselectivities. These regioisomers could be successfully separated and obtained in pure form. Major or minor regioisomers were determined as 4- or 3-fluoroalkylated isoquinolinones, respectively, based on X-ray crystallographic analyses.

SUBMITTER: Kumon T 

PROVIDER: S-EPMC8259111 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature