Atrial resting membrane potential confers sodium current sensitivity to propafenone, flecainide and dronedarone.

ABSTRACT:

Background

Although atrial fibrillation ablation is increasingly used for rhythm control therapy, antiarrhythmic drugs (AADs) are commonly used, either alone or in combination with ablation. The effectiveness of AADs is highly variable. Previous work from our group suggests that alterations in atrial resting membrane potential (RMP) induced by low Pitx2 expression could explain the variable effect of flecainide.

Objective

The purpose of this study was to assess whether alterations in atrial/cardiac RMP modify the effectiveness of multiple clinically used AADs.

Methods

The sodium channel blocking effects of propafenone (300 nM, 1 μM), flecainide (1 μM), and dronedarone (5 μM, 10 μM) were measured in human stem cell-derived cardiac myocytes, HEK293 expressing human Na

SUBMITTER: Holmes AP 

PROVIDER: S-EPMC8259123 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature