Plasma biomarker profiles and the correlation with cognitive function across the clinical spectrum of Alzheimer's disease.

ABSTRACT:

Background

Plasma biomarkers showed a promising value in the disease diagnosis and management of Alzheimer's disease (AD). However, profiles of the biomarkers and the associations with cognition across a spectrum of cognitive stages have seldom been reported.

Methods

We recruited 320 individuals with cognitive impairment and 131 cognitively normal participants from a memory clinic and a community cohort. Participants were classified into 6 groups based on their Clinical Dementia Rating (CDR) scores and clinical diagnosis, including AD, amnestic mild cognitive impairment (aMCI), and normal cognition (NC). A battery of neuropsychological tests was used to assess the global and domain-specific cognition. Plasma Aβ_1-40, Aβ_1-42, Aβ_1-42/Aβ_1-40

SUBMITTER: Xiao Z 

PROVIDER: S-EPMC8259165 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature