Mortality in acute pancreatitis with persistent organ failure is determined by the number, type, and sequence of organ systems affected.

ABSTRACT:

Background

Persistent organ failure (POF) is the strongest determinant of mortality in acute pancreatitis (AP). There is a paucity of data regarding the impact of different POF attributes on mortality and the role of different characteristics of systemic inflammatory response syndrome (SIRS) in the risk of developing POF.

Objective

We aimed to assess the association of POF dynamic features with mortality and SIRS characteristics with POF.

Methods

We studied 1544 AP subjects prospectively enrolled at 22 international centers (APPRENTICE consortium). First, we estimated the association of onset, duration, and maximal score of SIRS with POF. Then, we evaluated the risk of mortality based on POF onset, duration, number, type, and sequence of organs affected. Analyses were

SUBMITTER: Machicado JD 

PROVIDER: S-EPMC8259236 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature