The cost impact of unselective vs selective MammaPrint testing in early-stage breast cancer in Southern Africa.

ABSTRACT:

Background

MammaPrint (MP) has been applied in South Africa (SA) for decision-making in early-stage hormone receptor-positive breast cancer since 2006. The cost-impact of MP in SA has not been assessed.

Aim

To assess different MP testing strategies for cost-minimization in early-stage breast carcinoma using a funder perspective.

Methods

Clinico-pathologic information was extracted from a prospectively collected database. Clinical risk stratification was done using Adjuvant Online! (AOL) and the Predict V2.1 algorithm (www.predict.nhs.uk). An unselected MP testing strategy was compared to a selective strategy, testing only clinically high risk (cHigh) patients. Excluding human epidermal growth factor receptor-2 positive tumours, the costs for chemotherapy treatment and

SUBMITTER: Myburgh EJ 

PROVIDER: S-EPMC8259301 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature