Genetic variations at loci involved in the immune response are risk factors for hepatocellular carcinoma.

ABSTRACT:

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Primary liver cancer is the third most common cause of cancer-related death worldwide, with a rising incidence in Western countries. Little is known about the genetic etiology of this disease. To identify genetic factors associated with hepatocellular carcinoma (HCC) and liver cirrhosis (LC), we conducted a comprehensive, genome-wide variation analysis in a population of unrelated Asian individuals. Copy number variation (CNV) and single nucleotide polymorphisms (SNPs) were assayed in peripheral blood with the high-density Affymetrix SNP6.0 microarray platform. We used a two-stage discovery and replication design to control for overfitting and to validate observed results. We identified a strong association with CNV at the T-cell receptor gamma and alpha loci (P < 1 × 10

SUBMITTER: Clifford RJ 

PROVIDER: S-EPMC8259333 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature