Nampt controls skeletal muscle development by maintaining Ca²⁺ homeostasis and mitochondrial integrity.

ABSTRACT:

Objective

NAD⁺ is a co-factor and substrate for enzymes maintaining energy homeostasis. Nicotinamide phosphoribosyltransferase (NAMPT) controls NAD⁺ synthesis, and in skeletal muscle, NAD⁺ is essential for muscle integrity. However, the underlying molecular mechanisms by which NAD⁺ synthesis affects muscle health remain poorly understood. Thus, the objective of the current study was to delineate the role of NAMPT-mediated NAD⁺ biosynthesis in skeletal muscle development and function.

Methods

To determine the role of Nampt in muscle development and function, we generated skeletal muscle-specific Nampt KO (SMNKO) mice. We performed a comprehensive phenotypic characterization of the SMNKO mice, including metabolic measureme

SUBMITTER: Basse AL 

PROVIDER: S-EPMC8259345 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature