Molecular identification of an immunity- and Ferroptosis-related gene signature in non-small cell lung Cancer.

ABSTRACT:

Background

Lung cancer is one of the dominant causes of cancer-related deaths worldwide. Ferroptosis, an iron-dependent form of programmed cell death, plays a key role in cancer immunotherapy. However, the role of immunity- and ferroptosis-related gene signatures in non-small cell lung cancer (NSCLC) remain unclear.

Methods

RNA-seq data and clinical information pertaining to NSCLC were collected from The Cancer Genome Atlas dataset. Univariate and multivariate Cox regression analyses were performed to identify ferroptosis-related genes. A receiver operating characteristic (ROC) model was established for sensitivity and specificity evaluation. Gene ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway analyses were performed to explore the function roles of

SUBMITTER: Liu T 

PROVIDER: S-EPMC8259362 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature