Analysis of waveform and amplitude of mouse rod and cone flash responses.

ABSTRACT:

Key points

Most vertebrate eyes have rod and cone photoreceptors, which use a signal transduction pathway consisting of many biological processes to transform light into an electrical response. We dissect and quantify the contribution of each of these processes to the photoreceptor light response by using a novel method of analysis that provides an analytical solution for the entire time course of the dim-flash light response. We find that the shape of the light response is exclusively controlled by deactivation parameters. Activation parameters scale this shape and alter the response amplitude. We show that the rising phase of the response depends on Ca²⁺ feedback, and we identify the deactivation parameters that control the recovery phase of the response. We devise new

SUBMITTER: Abtout A 

PROVIDER: S-EPMC8259453 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature