Micropore Closure Rates following Microneedle Application at Various Anatomical Sites in Healthy Human Subjects.

ABSTRACT:

Introduction

The continuous availability of open micropores is crucial for a successful microneedle (MN) drug delivery strategy. However, micropore lifetime depends on intrinsic skin functional and anatomical characteristics, which vary significantly at different anatomical sites.

Objective

This pilot study explored if differences exist in micropore closure timeframes at 3 anatomical sites - upper arm, volar forearm, and abdomen.

Methods

Healthy subjects (n = 35) self-identifying as Asian (n = 9), Bi-/multiracial (n = 2), Black (n = 9), Latino (n = 6), and White (n = 9) completed the study. The upper arm, volar forearm, and abdomen were treated with MNs; skin impedance and transepidermal water loss (TEWL) were measured at baseline and post-MN to confirm micropore form

SUBMITTER: Ogunjimi AT 

PROVIDER: S-EPMC8259462 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature