Prasugrel and Ticagrelor in Patients with Drug-Eluting Stents and Kidney Failure.

ABSTRACT:

Background and objectives

Prasugrel and ticagrelor have superior efficacy compared with clopidogrel in moderate CKD but have not been studied in kidney failure. The study objective is to determine the effectiveness and safety of prasugrel and ticagrelor in kidney failure.

Design, setting, participants, & measurements

This retrospective cohort study used United States Renal Data System data from 2012 to 2015. We identified all patients on dialysis who received a drug-eluting stent and were alive at 90 days after stent implantation. Inverse probability-weighted Cox proportional hazard models were used. Weights were estimated with propensity scores for multiple treatments.

Results

This cohort included 6648 patients on clopidogrel, 621 on prasugrel, and 449 on ticagrelor.

SUBMITTER: Mavrakanas TA 

PROVIDER: S-EPMC8259486 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature