Deceased-Donor Acute Kidney Injury and BK Polyomavirus in Kidney Transplant Recipients.

ABSTRACT:

Background and objectives

BK polyomavirus (BKV) infection commonly complicates kidney transplantation, contributing to morbidity and allograft failure. The virus is often donor-derived and influenced by ischemia-reperfusion processes and disruption of structural allograft integrity. We hypothesized that deceased-donor AKI associates with BKV infection in recipients.

Design, setting, participants, & measurements

We studied 1025 kidney recipients from 801 deceased donors transplanted between 2010 and 2013, at 13 academic centers. We fitted Cox proportional-hazards models for BKV DNAemia (detectable in recipient blood by clinical PCR testing) within 1 year post-transplantation, adjusting for donor AKI and other donor- and recipient-related factors. We validated findings from th

SUBMITTER: Hall IE 

PROVIDER: S-EPMC8259491 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature