A multicomponent tetrazolo indole synthesis.

ABSTRACT: The ubiquitous presence of the indole fragment in natural products and drugs asks for ever novel syntheses. We report an unprecedented mild, two-step synthesis of 2-tetrazolo substituted indoles based on the Ugi-tetrazole reaction combined with an acidic ring closure. A gram-scale synthesis, a bioactive compound and further transformations were performed.

SUBMITTER: Lei X 

PROVIDER: S-EPMC8259579 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature