Renal Inflammation Induces Salt Sensitivity in Male db/db Mice through Dysregulation of ENaC.

ABSTRACT:

Background

Hypertension is considered a major risk factor for the progression of diabetic kidney disease. Type 2 diabetes is associated with increased renal sodium reabsorption and salt-sensitive hypertension. Clinical studies show that men have higher risk than premenopausal women for the development of diabetic kidney disease. However, the renal mechanisms that predispose to salt sensitivity during diabetes and whether sexual dimorphism is associated with these mechanisms remains unknown.

Methods

Female and male db/db mice exposed to a high-salt diet were used to analyze the progression of diabetic kidney disease and the development of hypertension.

Results

Male, 34-week-old, db/db mice display hypertension when exposed to a 4-week high-salt treatment, whereas equiv

SUBMITTER: Veiras LC 

PROVIDER: S-EPMC8259671 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature