BP in Young Adults with CKD and Associations with Cardiovascular Events and Decline in Kidney Function.

ABSTRACT:

Background

BP is an important modifiable risk factor for cardiovascular events and CKD progression in middle-aged or older adults with CKD. However, studies describing the relationship between BP with outcomes in young adults with CKD are limited.

Methods

In an observational study, we focused on 317 young adults (aged 21-40 years) with mild to moderate CKD enrolled in the Chronic Renal Insufficiency Cohort (CRIC) Study. Exposures included baseline systolic BP evaluated continuously (per 10 mm Hg increase) and in categories (<120, 120-129, and ≥130 mm Hg). Primary outcomes included cardiovascular events (heart failure, myocardial infarction, stroke, or all-cause death) and CKD progression (50% decline of eGFR or ESKD). We used Cox proportional hazard models to test associatio

SUBMITTER: Kula AJ 

PROVIDER: S-EPMC8259674 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature