Consolidation of human skill linked to waking hippocampo-neocortical replay.

ABSTRACT: The introduction of rest intervals interspersed with practice strengthens wakeful consolidation of skill. The mechanisms by which the brain binds discrete action representations into consolidated, highly temporally resolved skill sequences during waking rest are not known. To address this question, we recorded magnetoencephalography (MEG) during acquisition and rapid consolidation of a sequential motor skill. We report the presence of prominent, fast waking neural replay during the same rest periods in which rapid consolidation occurs. The observed replay is temporally compressed by approximately 20-fold relative to the acquired skill, is selective for the trained sequence, and predicts the magnitude of skill consolidation. Replay representations extend beyond the hippocampus and entorhina

SUBMITTER: Buch ER 

PROVIDER: S-EPMC8259719 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature