STAT3 Partly Inhibits Cell Proliferation via Direct Negative Regulation of FST Gene Expression.

ABSTRACT: Follistatin (FST) is a secretory glycoprotein and belongs to the TGF-β superfamily. Previously, we found that two single nucleotide polymorphisms (SNPs) of sheep FST gene were significantly associated with wool quality traits in Chinese Merino sheep (Junken type), indicating that FST is involved in the regulation of hair follicle development and hair trait formation. The transcription regulation of human and mouse FST genes has been widely investigated, and many transcription factors have been identified to regulate FST gene. However, to date, the transcriptional regulation of sheep FST is largely unknown. In the present study, genome walking was used to close the genomic gap upstream of the sheep genomic FST gene and to obtain the FST gene promote

SUBMITTER: Xu H 

PROVIDER: S-EPMC8259742 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature