In vivo kinetics of SARS-CoV-2 infection and its relationship with a person's infectiousness.

ABSTRACT: The within-host viral kinetics of SARS-CoV-2 infection and how they relate to a person's infectiousness are not well understood. This limits our ability to quantify the impact of interventions on viral transmission. Here, we develop data-driven viral dynamic models of SARS-CoV-2 infection and estimate key within-host parameters such as the infected cell half-life and the within-host reproductive number. We then develop a model linking VL to infectiousness, showing that a person's infectiousness increases sub-linearly with VL. We show that the logarithm of the VL in the upper respiratory tract (URT) is a better surrogate of infectiousness than the VL itself. Using data on VL and the predicted infectiousness, we further incorporated data on antigen and reverse transcription polymerase chain

SUBMITTER: Ke R 

PROVIDER: S-EPMC8259912 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature