GeneXpert on patients with human immunodeficiency virus and smear-negative pulmonary tuberculosis.

ABSTRACT:

Objectives

Vietnam is a high-prevalence country for tuberculosis (TB). Xpert MTB/RIF is a novel PCR-based diagnostic test that is substantially more sensitive for detecting M. tuberculosis than traditional smear-based techniques. However, locally-derived evidence of Xpert MTB/RIF in HIV-infected people is limited. This study evaluates the performance of the Xpert MTB/RIF in HIV-infected patients with smear-negative pulmonary TB (SNTB).

Methods

This was a cross-sectional study in 3 hospitals. The performance of Xpert MTB/RIF was compared with the reference standard of liquid culture and phenotypic drug-susceptibility testing for rifampicin (RIF) resistance.

Results

Out of 123 patients, the median age was 37.0 (IQR: 32.0-41.0) and 81.3% were male. The area under the rec

SUBMITTER: Cuong NK 

PROVIDER: S-EPMC8259960 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature