Multiscale modeling of tumor growth and angiogenesis: Evaluation of tumor-targeted therapy.

ABSTRACT: The dynamics of tumor growth and associated events cover multiple time and spatial scales, generally including extracellular, cellular and intracellular modifications. The main goal of this study is to model the biological and physical behavior of tumor evolution in presence of normal healthy tissue, considering a variety of events involved in the process. These include hyper and hypoactivation of signaling pathways during tumor growth, vessels' growth, intratumoral vascularization and competition of cancer cells with healthy host tissue. The work addresses two distinctive phases in tumor development-the avascular and vascular phases-and in each stage two cases are considered-with and without normal healthy cells. The tumor growth rate increases considerably as closed vessel loops (anastom

SUBMITTER: Jafari Nivlouei S 

PROVIDER: S-EPMC8259971 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature