PDBrenum: A webserver and program providing Protein Data Bank files renumbered according to their UniProt sequences.

ABSTRACT: The Protein Data Bank (PDB) was established at Brookhaven National Laboratories in 1971 as an archive for biological macromolecular crystal structures. In mid 2021, the database has almost 180,000 structures solved by X-ray crystallography, nuclear magnetic resonance, cryo-electron microscopy, and other methods. Many proteins have been studied under different conditions, including binding partners such as ligands, nucleic acids, or other proteins; mutations, and post-translational modifications, thus enabling extensive comparative structure-function studies. However, these studies are made more difficult because authors are allowed by the PDB to number the amino acids in each protein sequence in any manner they wish. This results in the same protein being numbered differently in the availa

SUBMITTER: Faezov B 

PROVIDER: S-EPMC8259974 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature