Dynamics of primitive streak regression controls the fate of neuromesodermal progenitors in the chicken embryo.

ABSTRACT: In classical descriptions of vertebrate development, the segregation of the three embryonic germ layers completes by the end of gastrulation. Body formation then proceeds in a head to tail fashion by progressive deposition of lineage-committed progenitors during regression of the primitive streak (PS) and tail bud (TB). The identification by retrospective clonal analysis of a population of neuromesodermal progenitors (NMPs) contributing to both musculoskeletal precursors (paraxial mesoderm) and spinal cord during axis formation challenged these notions. However, classical fate mapping studies of the PS region in amniotes have so far failed to provide direct evidence for such bipotential cells at the single-cell level. Here, using lineage tracing and single-cell RNA sequencing in the chicke

SUBMITTER: Guillot C 

PROVIDER: S-EPMC8260230 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature