PLOD2 Is a Potent Prognostic Marker and Associates with Immune Infiltration in Cervical Cancer.

ABSTRACT:

Background

PLOD2 is overexpressed in diverse tumors and plays a vital role in tumorigenesis. However, the prognostic value of PLOD2 in cervical cancer (CESC) remains unclear.

Methods

PLOD2 expression and CESC patients' survival data were collected from the Oncomine, GEPIA, UALCAN, and Kaplan-Meier Plotter databases; immunohistochemistry (IHC) was used to validate the expression of PLOD2 in CESC; Gene Set Enrichment Analysis was performed using the STRING and DAVID databases; and the correlations between PLOD2 and cancer immune infiltrates were investigated using the TIMER and TISIDB databases.

Results

We found that the expression level of PLOD2 was increased in various cancers, and meta-analysis in the Oncomine database revealed that PLOD2 was significantly upregulate

SUBMITTER: Li G 

PROVIDER: S-EPMC8260295 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature