Molecular nature and physiological role of the mitochondrial calcium uniporter channel.

ABSTRACT: Calcium (Ca²⁺) signaling is critical for cell function and cell survival. Mitochondria play a major role in regulating the intracellular Ca²⁺ concentration ([Ca²⁺]_i). Mitochondrial Ca²⁺ uptake is an important determinant of cell fate and governs respiration, mitophagy/autophagy, and the mitochondrial pathway of apoptosis. Mitochondrial Ca²⁺ uptake occurs via the mitochondrial Ca²⁺ uniporter (MCU) complex. This review summarizes the present knowledge on the function of MCU complex, regulation of MCU channel, and the role of MCU in Ca²⁺ homeostasis and human disease pathogenesis. The channel core consists of four MCU subunits and essential MCU regulators (EMRE). Regulatory proteins that interact with them

SUBMITTER: Alevriadou BR 

PROVIDER: S-EPMC8260355 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature