LRP1 regulates food intake and energy balance in GABAergic neurons independently of leptin action.

ABSTRACT: Low-density lipoprotein receptor-related protein 1 (LRP1) is a member of LDL receptor family that plays a key role in systemic glucose and lipid homeostasis. LRP1 also regulates energy balance in the hypothalamus by mediating leptin's anorexigenic action, although the underlying neurocircuitry involved is still unclear. Because GABAergic neurons are a major mediator of hypothalamic leptin action, we studied the role of GABAergic LRP1 in energy balance and leptin action using mice lacking LRP1 in Vgat- or AgRP-expressing neurons (Vgat-Cre; LRP1^loxP/loxP or AgRP-Cre; LRP1^loxP/loxP). Here, we show that LRP1 deficiency in GABAergic neurons results in severe obesity in male and female mice fed a normal-chow diet. This effect is most likely due to increased fo

SUBMITTER: Kang MC 

PROVIDER: S-EPMC8260358 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature