Development of an antiepileptogenesis drug screening platform: Effects of everolimus and phenobarbital.

ABSTRACT:

Objective

The kainic acid (KA)-induced status epilepticus (SE) model in rats is a well-defined model of epileptogenesis. This model closely recapitulates many of the clinical and pathological characteristics of human temporal lobe epilepsy (TLE) that arise following SE or another neurological insult. Spontaneous recurrent seizures (SRS) in TLE can present after a latent period following a neurological insult (traumatic brain injury, SE event, viral infection, etc.). Moreover, this model is suitable for preclinical studies to evaluate the long-term process of epileptogenesis and screen putative disease-modifying/antiepileptogenic agents. The burden of human TLE is highly variable, similar to the post-KA SE rat model. In this regard, this model may have broad translational relevance.

SUBMITTER: Barker-Haliski M 

PROVIDER: S-EPMC8260451 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature