TiO₂ supported single Ag atoms nanozyme for elimination of SARS-CoV2.

ABSTRACT: The outbreak of SARS-coronavirus 2 (SARS-CoV2) has become a global health emergency. Although enormous efforts have been made, there is still no effective treatment against the new virus. Herein, a TiO₂ supported single-atom nanozyme containing atomically dispersed Ag atoms (Ag-TiO₂ SAN) is designed to serve as a highly efficient antiviral nanomaterial. Compared with traditional nano-TiO₂ and Ag, Ag-TiO₂ SAN exhibits higher adsorption (99.65%) of SARS-CoV2 pseudovirus. This adsorption ability is due to the interaction between SAN and receptor binding domain (RBD) of spike 1 protein of SARS-CoV2. Theoretical calculation and experimental evidences indicate that the Ag atoms of SAN strongly bind to cysteine and asparagine, which are the most abundan

SUBMITTER: Wang D 

PROVIDER: S-EPMC8260506 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature