Evolution of frustrated and stabilising contacts in reconstructed ancient proteins.
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ABSTRACT:
SUBMITTER: Crippa M
PROVIDER: S-EPMC8260555 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Publications
Evolution of frustrated and stabilising contacts in reconstructed ancient proteins.
Crippa Martina M Andreghetti Damiano D Capelli Riccardo R Tiana Guido G
European biophysics journal : EBJ 20210211 5
Energetic properties of a protein are a major determinant of its evolutionary fitness. Using a reconstruction algorithm, dating the reconstructed proteins and calculating the interaction network between their amino acids through a coevolutionary approach, we studied how the interactions that stabilise 890 proteins, belonging to five families, evolved for billions of years. In particular, we focused our attention on the network of most strongly attractive contacts and on that of poorly optimised, ...[more]
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