Elevated resting heart rate as a predictor of inflammation and cardiovascular risk in healthy obese individuals.

ABSTRACT: The role of leukocyte inflammatory markers and toll like receptors (TLRs)2/4 in pathologies associated with elevated resting heart rate (RHR) levels in healthy obese (HO) individuals is not well elucidated. Herein, we investigated the relationship of RHR with expression of leukocyte-inflammatory markers and TLRs in HO individuals. 58-obese and 57-lean participants with no history of a major medical condition, were recruited in this study. In HO individuals, the elevated-RHR correlated positively with diastolic blood pressure, cholesterol, pro-inflammatory monocytes CD11b⁺CD11c⁺CD206^- phenotype (r = 0.52, P = 0.0003) as well as with activated T cells CD8⁺HLA-DR⁺ phenotype (r = 0.27, P = 0.039). No association was found between RHR and t

SUBMITTER: Al-Rashed F 

PROVIDER: S-EPMC8260607 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature