Association Between Kidney Clearance of Secretory Solutes and Cardiovascular Events: The Chronic Renal Insufficiency Cohort (CRIC) Study.

ABSTRACT:

Rationale & objective

The clearance of protein-bound solutes by the proximal tubules is an innate kidney mechanism for removing putative uremic toxins that could exert cardiovascular toxicity in humans. However, potential associations between impaired kidney clearances of secretory solutes and cardiovascular events among patients with chronic kidney disease (CKD) remains uncertain.

Study design

A multicenter, prospective, cohort study.

Setting & participants

We evaluated 3,407 participants from the Chronic Renal Insufficiency Cohort (CRIC) study.

Exposures

Baseline kidney clearances of 8 secretory solutes. We measured concentrations of secretory solutes in plasma and paired 24-hour urine specimens using liquid chromatography-tandem mass spectrometry (LC-MS/MS).

SUBMITTER: Chen Y 

PROVIDER: S-EPMC8260620 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature