GMP-compliant production of [⁶⁸Ga]Ga-NeoB for positron emission tomography imaging of patients with gastrointestinal stromal tumor.

ABSTRACT:

Background

[⁶⁸Ga]Ga-NeoB is a novel DOTA-coupled Gastrin Releasing Peptide Receptor (GRPR) antagonist with high affinity for GRPR and good in vivo stability. This study aimed at (1) the translation of preclinical results to the clinics and establish the preparation of [⁶⁸Ga]Ga-NeoB using a GMP conform kit approach and a licensed ⁶⁸Ge/⁶⁸Ga generator and (2) to explore the application of [⁶⁸Ga]Ga-NeoB in patients with gastrointestinal stromal tumors (GIST) before and/or after interventional treatment (selective internal radiotherapy, irreversible electroporation, microwave ablation).

Results

Validation of the production and quality control of [⁶⁸Ga]Ga-NeoB for patient use had to be performed before starting the

SUBMITTER: Pretze M 

PROVIDER: S-EPMC8260665 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature