Elucidating Axonal Injuries Through Molecular Modelling of Myelin Sheaths and Nodes of Ranvier.

ABSTRACT: Around half of the traumatic brain injuries are thought to be axonal damage. Disruption of the cellular membranes, or alternatively cytoskeletal damage has been suggested as possible injury trigger. Here, we have used molecular models to have a better insight on the structural and mechanical properties of axon sub-cellular components. We modelled myelin sheath and node of Ranvier as lipid bilayers at a coarse grained level. We built ex-novo a model for the myelin. Lipid composition and lipid saturation were based on the available experimental data. The model contains 17 different types of lipids, distributed asymmetrically between two leaflets. Molecular dynamics simulations were performed to characterize the myelin and node-of-Ranvier bilayers at equilibrium and under deformation and comp

SUBMITTER: Saeedimasine M 

PROVIDER: S-EPMC8260694 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature