From Transcript to Tissue: Multiscale Modeling from Cell Signaling to Matrix Remodeling.

ABSTRACT: Tissue-level biomechanical properties and function derive from underlying cell signaling, which regulates mass deposition, organization, and removal. Here, we couple two existing modeling frameworks to capture associated multiscale interactions-one for vessel-level growth and remodeling and one for cell-level signaling-and illustrate utility by simulating aortic remodeling. At the vessel level, we employ a constrained mixture model describing turnover of individual wall constituents (elastin, intramural cells, and collagen), which has proven useful in predicting diverse adaptations as well as disease progression using phenomenological constitutive relations. Nevertheless, we now seek an improved mechanistic understanding of these processes; we replace phenomenological relations in the mixt

SUBMITTER: Irons L 

PROVIDER: S-EPMC8260704 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature