Longitudinal Genomic Evolution of Conventional Papillary Thyroid Cancer With Brain Metastasis.

ABSTRACT:

Background

Brain metastasis is extremely rare but predicts dismal prognosis in papillary thyroid cancer (PTC). Dynamic evaluation of stepwise metastatic lesions was barely conducted to identify the longitudinal genomic evolution of brain metastasis in PTC.

Method

Chronologically resected specimen was analyzed by whole exome sequencing, including four metastatic lymph nodes (lyn 1-4) and brain metastasis lesion (BM). Phylogenetic tree was reconstructed to infer the metastatic pattern and the potential functional mutations.

Results

Contrasting with lyn1, ipsilateral metastatic lesions (lyn2-4 and BM) with shared biallelic mutations of TSC2 indicated different genetic originations from multifocal tumors. Lyn 3/4, particularly lyn4 exhibited high genetic similarity

SUBMITTER: Luo H 

PROVIDER: S-EPMC8260944 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature