Hypoxic Signaling in Skeletal Muscle Maintenance and Regeneration: A Systematic Review.

ABSTRACT: In skeletal muscle tissue, oxygen (O₂) plays a pivotal role in both metabolism and the regulation of several intercellular pathways, which can modify proliferation, differentiation and survival of cells within the myogenic lineage. The concentration of oxygen in muscle tissue is reduced during embryogenesis and pathological conditions. Myogenic progenitor cells, namely satellite cells, are necessary for muscular regeneration in adults and are localized in a hypoxic microenvironment under the basal lamina, suggesting that the O₂ level could affect their function. This review presents the effects of reduced oxygen levels (hypoxia) on satellite cell survival, myoblast regeneration and differentiation in vertebrates. Further investigations and understanding of the pathway

SUBMITTER: Pircher T 

PROVIDER: S-EPMC8260947 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature