The application of label-free imaging technologies in transdermal research for deeper mechanism revealing.

ABSTRACT: The penetration behavior of topical substances in the skin not only relates to the transdermal delivery efficiency but also involves the safety and therapeutic effect of topical products, such as sunscreen and hair growth products. Researchers have tried to illustrate the transdermal process with diversified theories and technologies. Directly observing the distribution of topical substances on skin by characteristic imaging is the most convincing approach. Unfortunately, fluorescence labeling imaging, which is commonly used in biochemical research, is limited for transdermal research for most topical substances with a molecular mass less than 500 Da. Label-free imaging technologies possess the advantages of not requiring any macromolecular dyes, no tissue destruction and an extensive subs

SUBMITTER: Zhang D 

PROVIDER: S-EPMC8261078 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature