The cardiac translational landscape reveals that micropeptides are new players involved in cardiomyocyte hypertrophy.

ABSTRACT: Hypertrophic growth of cardiomyocytes is one of the major compensatory responses in the heart after physiological or pathological stimulation. Protein synthesis enhancement, which is mediated by the translation of messenger RNAs, is one of the main features of cardiomyocyte hypertrophy. Although the transcriptome shift caused by cardiac hypertrophy induced by different stimuli has been extensively investigated, translatome dynamics in this cellular process has been less studied. Here, we generated a nucleotide-resolution translatome as well as transcriptome data from isolated primary cardiomyocytes undergoing hypertrophy. More than 10,000 open reading frames (ORFs) were detected from the deep sequencing of ribosome-protected fragments (Ribo-seq), which orchestrated the shift of the transla

SUBMITTER: Yan Y 

PROVIDER: S-EPMC8261087 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature