Role of NRP1 in Bladder Cancer Pathogenesis and Progression.

ABSTRACT: Bladder urothelial carcinoma (BC) is a fatal invasive malignancy and the most common malignancy of the urinary system. In the current study, we investigated the function and mechanisms of Neuropilin-1 (NRP1), the co-receptor for vascular endothelial growth factor, in BC pathogenesis and progression. The expression of NRP1 was evaluated using data extracted from GEO and HPA databases and examined in BC cell lines. The effect on proliferation, apoptosis, angiogenesis, migration, and invasion of BC cells were validated after NRP1 knockdown. After identifying differentially expressed genes (DEGs) induced by NRP1 silencing, GO/KEGG and IPA^® bioinformatics analyses were performed and specific predicted pathways and targets were confirmed in vitro. Additionally, th

SUBMITTER: Dong Y 

PROVIDER: S-EPMC8261128 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature