A phylogeny-aware approach reveals unexpected venom components in divergent lineages of cone snails.

ABSTRACT: Marine gastropods of the genus Conus are renowned for their remarkable diversity and deadly venoms. While Conus venoms are increasingly well studied for their biomedical applications, we know surprisingly little about venom composition in other lineages of Conidae. We performed comprehensive venom transcriptomic profiling for Conasprella coriolisi and Pygmaeconus traillii, first time for both respective genera. We complemented reference-based transcriptome annotation by a de novo toxin prediction guided by phylogeny, which involved transcriptomic data on two additional 'divergent' cone snail lineages, Profundiconus, and Californiconus. We identified toxin clusters (SSCs) shared among all or some of the four analysed genera based on the ident

SUBMITTER: Fedosov A 

PROVIDER: S-EPMC8261202 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature