A network-biology approach for identification of key genes and pathways involved in malignant peritoneal mesothelioma.

ABSTRACT: Even in the current age of advanced medicine, the prognosis of malignant peritoneal mesothelioma (MPM) remains abysmal. Molecular mechanisms responsible for the initiation and progression of MPM are still largely not understood. Adopting an integrated bioinformatics approach, this study aims to identify the key genes and pathways responsible for MPM. Genes that are differentially expressed in MPM in comparison with the peritoneum of healthy controls have been identified by analyzing a microarray gene expression dataset. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses of these differentially expressed genes (DEG) were conducted to gain a better insight. A protein-protein interaction (PPI) network of the proteins encoded by the DEGs was constructed using STRING and

SUBMITTER: Mahfuz AMUB 

PROVIDER: S-EPMC8261271 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature