Trends in urine biomarker discovery for urothelial bladder cancer: DNA, RNA, or protein?

ABSTRACT: Urothelial bladder cancer is a complex disease displaying a landscape of heterogenous molecular subtypes, mutation profiles and clinical presentations. Diagnosis and surveillance rely on flexible cystoscopy which has high accuracy, albeit accompanied by a high-cost burden for healthcare providers and discomfort for patients. Advances in "omic" technologies and computational biology have provided insights into the molecular pathogenesis of bladder cancer and provided powerful tools to identify markers for disease detection, risk stratification, and predicting responses to therapy. To date, numerous attempts have been made to discover and validate diagnostic biomarkers that could be deployed as an adjunct to the cystoscopic diagnosis and long-term surveillance of bladder cancer. We report a

SUBMITTER: Humayun-Zakaria N 

PROVIDER: S-EPMC8261432 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature