Immune-related long non-coding RNAs can serve as prognostic biomarkers for clear cell renal cell carcinoma.

ABSTRACT:

Background

The immune microenvironment is a critical regulator of clear cell renal cell carcinoma (ccRCC) progression. However, the underlying mechanisms the regulatory role of immune-related long non-coding RNAs (irlncRNAs) in the ccRCC tumor microenvironment (TME) are still obscure. Herein, we investigated prognostics role of irlncRNAs for ccRCC.

Methods

The raw data of patients with ccRCC were downloaded from The Cancer Genome Atlas (TCGA) database, and immune-related genes were obtained from the ImmPort database. First, we investigated the correlation between the immune-related genes and irlncRNAs. Then, we identified the differentially expressed irlncRNA pairs (ILRPs) between normal and cancer tissue samples, and prognostic model was constructed with the differentially

SUBMITTER: Li CS 

PROVIDER: S-EPMC8261450 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature