Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) patients frequently suffer from undetected micro-metastatic disease. This clinical situation would greatly benefit from additional investigation. Therefore, we set out to identify key signalling events that drive metastatic evolution from the pancreas. We searched for a gene signature that discriminate localised PDAC from confirmed metastatic PDAC and devised a preclinical protocol using circulating cell-free DNA (cfDNA) as an early biomarker of micro-metastatic disease to validate the identification of key signalling events. An unbiased approach identified, amongst actionable markers of disease progression, the PI3K pathway and a distinctive PI3Kα activation signature as predictive of PDAC aggressiveness and prognosis. Pharmacological or tumour-rest

SUBMITTER: Thibault B 

PROVIDER: S-EPMC8261517 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature