Hematopoietic stem cell transplantation for thalassemia major using HLA fully-matched and mismatched donor grafts.

ABSTRACT:

Background

Until now, allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only effective method to cure Thalassemia major. However, it has not been determined whether similar results can be obtained with the same conditioning regimen for both fully-matched and mismatched donors grafts. We hypothesized that using modified NF-08-TM conditioning regimen could achieve similar results for both fully and mismatched donors grafts.

Methods

This retrospective cohort study included patients with β-thalassemia major who underwent HSCT with modified NF-08-TM conditioning regimen at Guangzhou Women and Children's Medical Centre between January 2013 and January 2019.

Results

Among the 257 patients (172 males) included in this study, 3 had two transplantations. Tot

SUBMITTER: Huang C 

PROVIDER: S-EPMC8261584 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature